The Power of Nutrition
in Curing Cancer

Cancer pathomechanism

Peter Grandics
A-D Research Foundation, 5922 Farnsworth Ct, Carlsbad, CA 92008, USA

A-D Research Foundation is committed to:

  • Developing a new understanding of the patho-mechanism of cancer
  • Developing new, breakthrough therapies by utilizing this knowledge
cancer pathomechanism

Currently held views on cancer mechanism

Main Emphasis on Genetics:
  • From a single cell that loses its differentiated state through sequential mutations
  • Initiation-promotion-progression concept explains the steps in a sequential process
  • Oncogenic theories suggests that defects in tumor suppressor genes cause malignancy

The cancer stem cell concept

  • Cancer may develop out of a single cell
  • Just a small fraction of tumor cells have the ability of disease propagation
  • Cancer stem cells could be mutated normal stem cells
  • Cancer stem cells may develop from other cell types

Observations & Analysis

  • Body mounts a low intensity immune response to cancer
  • Immunosuppressive cytotoxic antineoplastic therapies may cause regression of a clinically established cancer
  • Immunosuppression that can be lethal in a fungal infection may benefit cancer suppression
  • Autoimmunity is also controlled by immunosuppression
  • Cancer cells “attack self” comparably to autoreactive T cells
  • Could there be a relationship between autoimmunity and cancer?
  • Could the cancer stem cell arise from damaged autoreactive
  • T cells?

Comparison of inflammatory cells and cancer cells

Inflammatory T cells:
  • Inflammatory cytokine secretion
  • Attachment to neutrophils, macrophages, endothelium
  • Cause platelet aggregation
  • Secrete tissue factor
  • Induce clotting
  • Temporary wound stroma development
Cancer cells:

All the same except that the wound stroma is permanent (tumor)

Infection, inflammation & cancer

  • Microbial antigens are present in the patient’s sera
  • Pathogen eradicating therapy led to the regression of some cancers
  • Hit-and-stay pathogens distort the immune response using the TLR signaling system
  • Th2, Treg dominance established
  • Th2 cytokines antagonize cellular immune response
  • Tumor cells secrete Th2 polarizing cytokines that inhibit tumor specific cytotoxic T cells

Infection, autoimmunity & cancer

  • A number of pathogens are linked to autoimmunity & cancer
  • Antinuclear antibodies (ANA) were found in the sera of 19% of patients
  • Autoantibodies are observed against tissue-specific antigens, nucleoproteins, membrane receptors, proliferation-associated antigens, tissue-restricted antigens,
  • About 60% of cancers express anti-p53 autoAbs
  • Infections may induce autoimmune serological features without overt autoimmune disease or organ involvement
  • Cancer patients exhibit a higher percentage of autoreactive T cells
  • Mechanism of autoimmunity via molecular mimicry

References